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Cheap flights from Des Moines to St. Louis from $75

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to St. Louis departing on 2/21. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to St. Louis

Cheap round-trip flights

These are some of the best round-trip flight deals from Des Moines to St. Louis that have been recently found on momondo from popular airlines, departing in the coming months.

Cheap one-way flights

Flying one-way? These are some of the best deals recently discovered on momondo for flights from Des Moines to St. Louis.

Cheap last minute flights

Planning a quick getaway from Des Moines to St. Louis? These are the last-minute flight deals available now.

Cheap direct flights

If you prefer a non-stop journey, check out our latest direct flight deals to St. Louis, so you can enjoy a seamless trip without layovers.

Cheap bus & train deals from Des Moines to St. Louis

Find recent round-trip train or bus tickets from Des Moines to St. Louis.

All round-trip flight deals to St. Louis

The cheapest plane tickets to St. Louis found on KAYAK recently.
5:45 am - 9:36 amDSM-STL
3h 51m1 stop
5:40 am - 11:35 amSTL-DSM
5h 55m1 stop
$162American Airlines
Find Deal
Fri, Jan 3 - Wed, Jan 8
6:34 pm - 11:43 pmDSM-STL
5h 09m1 stop
6:00 am - 11:40 amSTL-DSM
5h 40m1 stop
$182Delta
Find Deal
Thu, Dec 12 - Mon, Dec 16
5:35 pm - 10:06 pmDSM-STL
4h 31m1 stop
6:00 am - 11:30 amSTL-DSM
5h 30m1 stop
$186Delta
Find Deal
Mon, Dec 30 - Mon, Jan 6
6:34 pm - 11:43 pmDSM-STL
5h 09m1 stop
10:21 am - 8:55 pmSTL-DSM
10h 34m2 stops
$193Delta
Find Deal
Thu, Dec 12 - Mon, Dec 16
6:34 pm - 11:43 pmDSM-STL
5h 09m1 stop
6:00 am - 11:40 amSTL-DSM
5h 40m1 stop
$218Delta
Find Deal
Thu, Dec 12 - Mon, Dec 16
5:30 am - 6:50 amDSM-STL
1h 20mnonstop
10:30 am - 7:10 pmSTL-DSM
8h 40m1 stop
$228Southwest
Find Deal
Mon, Dec 30 - Mon, Jan 6
5:30 am - 6:50 amDSM-STL
1h 20mnonstop
8:15 pm - 9:25 pmSTL-DSM
1h 10mnonstop
$229Southwest
Find Deal
Mon, Dec 30 - Mon, Jan 6
5:45 am - 11:32 amDSM-STL
5h 47m1 stop
5:45 am - 11:35 amSTL-DSM
5h 50m1 stop
$237American Airlines
Find Deal
Sat, Jan 4 - Sat, Jan 11
8:00 am - 2:24 pmDSM-STL
6h 24m1 stop
6:30 am - 10:35 amSTL-DSM
4h 05m1 stop
$283United Airlines
Find Deal
Fri, Jan 3 - Fri, Jan 10
8:00 am - 12:26 pmDSM-STL
4h 26m1 stop
8:00 am - 8:32 pmSTL-DSM
12h 32m2 stops
$426United Airlines
Find Deal
Sat, Jan 4 - Sat, Jan 11
8:41 pm - 9:16 amDSM-STL
12h 35m1 stop
$75Frontier
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Fri, Feb 21
12:15 pm - 4:20 pmDSM-STL
4h 05m1 stop
$79American Airlines
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Tue, Jan 21
6:00 pm - 10:09 pmDSM-STL
4h 09m1 stop
$83American Airlines
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Fri, Jan 24
4:00 pm - 5:10 pmDSM-STL
1h 10mnonstop
$84Southwest
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Tue, Jan 21
11:19 am - 3:57 pmDSM-STL
4h 38m1 stop
$88Delta
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Wed, Dec 18
5:35 pm - 10:06 pmDSM-STL
4h 31m1 stop
$93Delta
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Thu, Dec 19
8:00 am - 2:24 pmDSM-STL
6h 24m1 stop
$108United Airlines
Find Deal
Tue, Dec 24
8:00 am - 2:14 pmDSM-STL
6h 14m1 stop
$123United Airlines
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Mon, Jan 20
4:00 pm - 5:10 pmDSM-STL
1h 10mnonstop
$155Southwest
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Fri, Jan 24
2:41 pm - 12:10 pmDSM-STL
45h 29m3 stops
Fri, Jan 24
7:06 pm - 12:06 amDSM-STL
5h 00m1 stop
5:38 pm - 5:37 pmSTL-DSM
23h 59m1 stop
$338Frontier
Find Deal
Fri, Nov 22 - Sun, Nov 24
8:00 am - 4:26 pmDSM-STL
8h 26m1 stop
9:50 am - 8:03 pmSTL-DSM
10h 13m2 stops
Sun, Nov 24 - Sun, Dec 1
6:35 am - 2:10 pmDSM-STL
7h 35m1 stop
5:15 am - 12:15 pmSTL-DSM
7h 00m1 stop
$633Southwest
Find Deal
Sat, Nov 23 - Sun, Dec 1
5:30 am - 6:50 amDSM-STL
1h 20mnonstop
5:15 am - 12:15 pmSTL-DSM
7h 00m1 stop
$634Southwest
Find Deal
Sat, Nov 23 - Sun, Dec 1
6:45 pm - 7:50 pmDSM-STL
1h 05mnonstop
9:55 am - 11:05 amSTL-DSM
1h 10mnonstop
$635Southwest
Find Deal
Sat, Nov 23 - Sun, Dec 1
5:20 am - 9:29 amDSM-STL
4h 09m1 stop
11:35 am - 2:52 pmSTL-DSM
3h 17m1 stop
$647American Airlines
Find Deal
Fri, Nov 22 - Fri, Nov 22
2:24 pm - 9:03 pmDSM-STL
6h 39m1 stop
5:34 pm - 10:43 pmSTL-DSM
5h 09m1 stop
$652Delta
Find Deal
Fri, Nov 22 - Sun, Nov 24
7:00 am - 1:15 pmDSM-STL
6h 15m2 stops
5:34 pm - 10:43 pmSTL-DSM
5h 09m1 stop
$657Delta
Find Deal
Fri, Nov 22 - Fri, Nov 22
11:25 am - 3:39 pmDSM-STL
4h 14m1 stop
12:00 pm - 9:46 pmSTL-DSM
9h 46m2 stops
$887United Airlines
Find Deal
Fri, Nov 22 - Sun, Nov 24
3:20 pm - 9:36 pmDSM-STL
6h 16m1 stop
12:37 pm - 9:46 pmSTL-DSM
9h 09m2 stops
$915United Airlines
Find Deal
Fri, Nov 22 - Sun, Nov 24
5:30 am - 6:50 amDSM-STL
1h 20mnonstop
8:15 pm - 9:25 pmSTL-DSM
1h 10mnonstop
$229Southwest
Find Deal
Mon, Dec 30 - Mon, Jan 6
9:00 am - 10:20 amDSM-STL
1h 20mnonstop
10:15 am - 11:25 amSTL-DSM
1h 10mnonstop
$310Southwest
Find Deal
Sat, Jan 11 - Sun, Jan 12
8:00 am - 9:10 amDSM-STL
1h 10mnonstop
9:55 am - 11:05 amSTL-DSM
1h 10mnonstop
$350Southwest
Find Deal
Sat, Mar 22 - Mon, Mar 24
4:10 pm - 5:15 pmDSM-STL
1h 05mnonstop
9:55 am - 11:05 amSTL-DSM
1h 10mnonstop
$394Southwest
Find Deal
Fri, Dec 6 - Sun, Dec 8

American Airlines flights from Des Moines to St. Louis

Our best American Airlines deals on Des Moines to St. Louis flight tickets
American Airlines
Jan 3
DSM5:45 amDes Moines
3h 51m
1 stop
STL9:36 amLambert-St Louis
Jan 8
STL5:40 amLambert-St Louis
5h 55m
1 stop
DSM11:35 amDes Moines
American Airlines
Jan 4
DSM5:45 amDes Moines
5h 47m
1 stop
STL11:32 amLambert-St Louis
Jan 11
STL5:45 amLambert-St Louis
5h 50m
1 stop
DSM11:35 amDes Moines
American Airlines
Jan 11
DSM1:01 pmDes Moines
5h 22m
1 stop
STL6:23 pmLambert-St Louis
Jan 12
STL5:44 amLambert-St Louis
5h 51m
1 stop
DSM11:35 amDes Moines

Delta flights from Des Moines to St. Louis

Our best Delta deals on Des Moines to St. Louis flight tickets
Delta
Dec 12
DSM6:34 pmDes Moines
5h 09m
1 stop
STL11:43 pmLambert-St Louis
Dec 16
STL6:00 amLambert-St Louis
5h 40m
1 stop
DSM11:40 amDes Moines
Delta
Dec 30
DSM5:35 pmDes Moines
4h 31m
1 stop
STL10:06 pmLambert-St Louis
Jan 6
STL6:00 amLambert-St Louis
5h 30m
1 stop
DSM11:30 amDes Moines
Delta
Dec 12
DSM6:34 pmDes Moines
5h 09m
1 stop
STL11:43 pmLambert-St Louis
Dec 16
STL10:21 amLambert-St Louis
10h 34m
2 stops
DSM8:55 pmDes Moines

See travel insights to St. Louis from

How to get the cheapest flight ticket from Des Moines to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, August is the cheapest month to fly from Des Moines to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $258. The month of January is another great option to travel to St. Louis, with average flight prices from Des Moines averaging around $281.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Saturday when prices can be found for as low as $284. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $444. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Des Moines at noon is the least expensive time of day to depart. momondo users have found prices as low as $0 when looking at flights departing at noon. In the afternoon is when there is more demand to fly to St. Louis, so prices are often more expensive at around $424 per ticket.

What is the cheapest Des Moines to Lambert-St Louis flight route?

Fly from Des Moines to Lambert-St Louis for the best Des Moines - Lambert-St Louis flight prices

What cabin class options are available on Des Moines to Lambert-St Louis flights?

There are 1 cabin classes available to choose from on Des Moines to Lambert-St Louis flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

Can stopping save me money on Des Moines to St. Louis flights?

You could potentially save up to 10% on your flight if you consider stops on a Des Moines to St. Louis flight.

How have Des Moines to St. Louis flight prices changed over time?

As of November 2024, prices for Des Moines to St. Louis flights are approximately 79% cheaper when compared to flights at the same time last year.

When to book flights from Des Moines to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to St. Louis (DSM to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to St. Louis

Best Price Found

$75

Fastest flight time

1h 05m

Direct flights

Mon, Tue, Wed, Sat and Sun

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Des Moines in the past 72 hours is $75. The best round-trip flight deal from Des Moines to St. Louis found on momondo in the last 72 hours is $162.
The fastest flight from Des Moines to St. Louis takes 1h 05m
Direct flights go from Des Moines to St. Louis on Monday, Tuesday, Wednesday, Saturday and Sunday. The only airline offering direct flights is Southwest.
There is 1 airport near St. Louis: Lambert-St Louis (STL)

  • How far is Des Moines to Lambert-St Louis by plane?

    A flight from Des Moines to Lambert-St Louis will travel around 273.0 mi. Flights usually cover this in 1h 05m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Lambert-St Louis Airport?

    Prices for flights from Des Moines Airport to Lambert-St Louis Airport refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Des Moines Airport to Lambert-St Louis Airport?

    The minimum age for a child to fly alone is five, but airlines that offer an unaccompanied minor (UNMR) service may have their own age limitations. Flight duration, scheduling, and layovers are among the considerations that may influence age limits. We recommend that you double-check with the airline you are booking with for travel from Des Moines Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Des Moines to St. Louis?

  • What is the most popular airline from Des Moines to St. Louis?


Best airlines flying from Des Moines to St. Louis

Compare and see reviews for airlines that fly from Des Moines to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $155Free CancellationRating
8.0
8,755 reviews
Search Delta flights
SouthwestPriceFrom $168Free CancellationRating
8.1
5,005 reviews
Search Southwest flights
American AirlinesPriceFrom $257Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $258Free CancellationRating
7.4
9,172 reviews
Search United Airlines flights
  • Southwest Flights From Des Moines to St. Louis

    The lowest priced Southwest flight from Des Moines to St. Louis from the last 72 hours was $168. Generally, Southwest has 8 flights on this route every week with an average price of $320. Southwest is rated 8.1/10 by our users.


Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to St. Louis?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to St. Louis for you.

Can I find flights from Des Moines to St. Louis with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to St. Louis from Des Moines with this policy.

How can momondo help me find flights from Des Moines to St. Louis?

Once all potential Des Moines to St. Louis flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Des Moines to St. Louis right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to St. Louis flights. All you need is a valid email address and we will do the rest; it is that quick and easy.


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