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Cheap flights from Des Moines to Charleston from $128

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to Charleston departing on 5/16. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
1 adult
0 bags

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Find the cheapest flights from Des Moines to Charleston

Cheap round-trip flights

KAYAK's recommended round-trip deals from the most popular airlines that fly from Des Moines to Charleston.
 Logo
2:28 pm - 10:12 amDSM-CHS
18h 44m1 stop
 Logo
10:32 am - 9:58 pmCHS-DSM
12h 26m1 stop
Fri, May 2 - Mon, May 5
 Logo
1:31 pm - 4:25 pmDSM-CHS
25h 54m2 stops
 Logo
10:32 am - 9:58 pmCHS-DSM
12h 26m1 stop
Fri, May 2 - Mon, May 5
American Airlines Logo
5:15 am - 11:48 amDSM-CHS
5h 33m1 stop
American Airlines Logo
7:04 pm - 11:49 pmCHS-DSM
5h 45m1 stop
$297American Airlines
Find Deal
Sat, May 31 - Sat, Jun 7
United Airlines Logo
3:38 pm - 9:33 pmDSM-CHS
4h 55m1 stop
United Airlines Logo
3:51 pm - 9:47 pmCHS-DSM
6h 56m1 stop
$300United Airlines
Find Deal
Thu, Aug 7 - Tue, Aug 12
American Airlines Logo
5:15 am - 11:48 amDSM-CHS
5h 33m1 stop
American Airlines Logo
6:34 pm - 11:52 pmCHS-DSM
6h 18m2 stops
$302American Airlines
Find Deal
Sat, May 31 - Sat, Jun 7
United Airlines Logo
3:38 pm - 9:33 pmDSM-CHS
4h 55m1 stop
United Airlines Logo
6:15 am - 2:41 pmCHS-DSM
9h 26m2 stops
$305United Airlines
Find Deal
Thu, Aug 7 - Tue, Aug 12
Delta Logo
2:15 pm - 9:35 pmDSM-CHS
6h 20m1 stop
Delta Logo
9:40 am - 1:25 pmCHS-DSM
4h 45m1 stop
$335Delta
Find Deal
Fri, May 2 - Fri, May 9
Delta Logo
2:15 pm - 9:35 pmDSM-CHS
6h 20m1 stop
Delta Logo
6:37 am - 12:27 pmCHS-DSM
6h 50m2 stops
$340Delta
Find Deal
Fri, May 2 - Fri, May 9
Southwest Logo
6:10 am - 5:05 pmDSM-CHS
9h 55m2 stops
Southwest Logo
6:10 am - 11:05 amCHS-DSM
5h 55m2 stops
$351Southwest
Find Deal
Sat, Aug 9 - Thu, Aug 14
Southwest Logo
6:00 am - 5:55 pmDSM-CHS
10h 55m2 stops
Southwest Logo
6:35 am - 2:40 pmCHS-DSM
9h 05m2 stops
$368Southwest
Find Deal
Thu, Aug 7 - Tue, Aug 12

American Airlines flights from Des Moines to Charleston

Our best American Airlines deals on Des Moines to Charleston flight tickets
American Airlines
May 31
DSM5:15 amDes Moines
5h 33m
1 stop
CHS11:48 amCharleston
Jun 7
CHS7:04 pmCharleston
5h 45m
1 stop
DSM11:49 pmDes Moines
American Airlines
May 31
DSM5:15 amDes Moines
5h 33m
1 stop
CHS11:48 amCharleston
Jun 7
CHS6:34 pmCharleston
6h 18m
2 stops
DSM11:52 pmDes Moines
American Airlines
May 2
DSM12:25 pmDes Moines
5h 35m
1 stop
CHS7:00 pmCharleston
May 10
CHS6:25 amCharleston
6h 53m
1 stop
DSM12:18 pmDes Moines

United Airlines flights from Des Moines to Charleston

Our best United Airlines deals on Des Moines to Charleston flight tickets
United Airlines
Aug 7
DSM3:38 pmDes Moines
4h 55m
1 stop
CHS9:33 pmCharleston
Aug 12
CHS3:51 pmCharleston
6h 56m
1 stop
DSM9:47 pmDes Moines
United Airlines
Aug 7
DSM3:38 pmDes Moines
4h 55m
1 stop
CHS9:33 pmCharleston
Aug 12
CHS6:15 amCharleston
9h 26m
2 stops
DSM2:41 pmDes Moines
United Airlines
Apr 19
DSM8:00 amDes Moines
4h 59m
1 stop
CHS1:59 pmCharleston
Apr 23
CHS11:40 amCharleston
7h 26m
1 stop
DSM6:06 pmDes Moines

See travel insights to Charleston from

How to get the cheapest flight ticket from Des Moines to Charleston

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Charleston?

The cheapest month to fly to Charleston from Des Moines is in September. Flight prices, which tend to average around $349, are often lower during this time because this is during the off-season. The month of October is another great option to travel to Charleston, with average flight prices from Des Moines averaging around $361.

What is the cheapest day to depart on your flight to Charleston?

The cheapest day to depart from Des Moines to Charleston is on a Monday. Travelers who choose to depart for Charleston on a Monday will often find tickets for as low as $379. The most expensive day to fly to Charleston is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to Charleston?

The cheapest time of day to fly to Charleston is in the afternoon when flights can be purchased for as low as $386. In the morning is when there is more demand to fly to Charleston, so prices are often more expensive at around $405 per ticket.

How far in advance should I book a flight to Charleston?

You are more likely to see cheaper flights to Charleston from Des Moines when booking 10 weeks ahead of your departure date. In general, you can expect to find flights to Charleston for around $408 when searching 10 weeks out.However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Charleston from Des Moines for as low as $327 on momondo.

How have Des Moines to Charleston flight prices changed over time?

As of April 2025, prices for Des Moines to Charleston flights are approximately 123% more expensive when compared to flights at the same time last year.

When to book flights from Des Moines to Charleston

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Charleston according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Des Moines to Charleston (DSM to CHS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Charleston

Best Price Found

$128

Fastest flight time

4h 06m

Direct flights

None

Airports in Charleston

1 airport
The best one-way flight to Charleston from Des Moines in the past 72 hours is $128. The best round-trip flight deal from Des Moines to Charleston found on momondo in the last 72 hours is $226.
The fastest flight from Des Moines to Charleston takes 4h 06m
There are no direct flights from Des Moines to Charleston. Popular non-direct route for this connection is Des Moines Airport - Charleston Airport.
There is 1 airport near Charleston: Charleston (CHS)

  • How far is Des Moines to Charleston by plane?

    The distance between Des Moines and Charleston is about 966.2 mi. Flights usually cover this in 4h 06m, depending on flying conditions and air traffic around both airports.

  • When did momondo last update prices for flights from Des Moines Airport to Charleston Airport?

    Prices for flights from Des Moines Airport to Charleston Airport were last updated today.

  • How many operators does momondo search for flights from Des Moines Airport to Charleston Airport?

  • How old do you have to be to fly from Des Moines Airport to Charleston Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Charleston Airport.

  • What documentation or ID do you need to fly to Charleston Airport?

    The travel and health documents required for your trip to Charleston Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Charleston Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

  • What is the most popular airline from Des Moines to Charleston?


Best airlines flying from Des Moines to Charleston

Compare and see reviews for airlines that fly from Des Moines to Charleston with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $258Free CancellationRating
8.0
7,901 reviews
Search Delta flights
American AirlinesPriceFrom $263Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $311Free CancellationRating
7.4
8,621 reviews
Search United Airlines flights

Traveling to a place near Charleston?

Book flights to Charleston if you plan to visit one of these locations
Folly Beach
North Charleston
Isle of Palms
Mount Pleasant
Summerville
Kiawah Island
Edisto Beach
Walterboro
Edisto Island
Goose Creek
Santee
Seabrook Island

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Charleston?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Des Moines to Charleston. momondo saves you time and could save you money on your trip.

Can I find flights from Des Moines to Charleston with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to Charleston flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to Charleston?

momondo helps you find the best flight between Des Moines and Charleston by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to Charleston right now. Can momondo alert me if prices change?

Yes. momondo can track prices for Des Moines to Charleston flights and alert you when they change. Perform a search to set up the price alert. All that is required is a valid email address.


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