What airlines fly to Buffalo?

American Airlines, Delta and United Airlines are the top three most popular airlines that fly to Buffalo from Des Moines according to our data. American Airlines is the first choice among our users, with 42% of people opting to fly with this airline when traveling to Buffalo. Keep in mind that there are 3 different airlines that fly to Buffalo on a routine basis, so you have a few additional options to choose from.

What is the cheapest airline that flies from Des Moines to Buffalo?

Delta, American Airlines, and United Airlines are the most popular carriers operating from Des Moines to Buffalo

When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?

Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.

How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?

As of February 2025, there are 3 operators available to choose from for flights from Des Moines Airport to Buffalo Airport.

How old do you have to be to fly from Des Moines Airport to Buffalo Airport?

The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.

What documentation or ID do you need to fly to Buffalo Airport?

The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.

$184 Discover Cheap Flights from Des Moines to Buffalo in 2025

1 adult

0 bags

Deals available from 900+ travel sites.

Save money when you book flights with momondo

Big names and deals

Search 100s of travel sites to compare prices.

Filter for what you want

Free Wi-Fi? Stopover? Instantly customize your results.

Trusted and free

We’re completely free to use - no hidden charges or fees.

Price Alerts

Not ready to book? to track prices.

Search flight deals

Find the cheapest flights from Des Moines to Buffalo

Round-trip

One-way

Last minute

Cheap round-trip flights

These are some of the best round-trip flight deals from Des Moines to Buffalo that have been recently found on momondo from popular airlines, departing in the coming months.

7:15 am - 2:18 pmDSM-BUF

6h 03m1 stop

6:00 am - 10:41 amBUF-DSM

5h 41m1 stop

$368Delta

Find Deal

Fri, Apr 18 - Wed, Apr 23

6:45 am - 2:29 pmDSM-BUF

6h 44m1 stop

6:00 am - 1:13 pmBUF-DSM

8h 13m2 stops

$377American Airlines

Find Deal

Fri, Apr 18 - Wed, Apr 23

6:50 am - 12:16 pmDSM-BUF

4h 26m1 stop

6:00 am - 1:40 pmBUF-DSM

8h 40m2 stops

$382American Airlines

Find Deal

Thu, Mar 20 - Thu, Mar 27

6:38 am - 3:27 pmDSM-BUF

7h 49m2 stops

6:00 am - 1:40 pmBUF-DSM

8h 40m2 stops

$387American Airlines

Find Deal

Thu, Mar 20 - Thu, Mar 27

5:25 am - 1:40 pmDSM-BUF

7h 15m2 stops

5:05 am - 12:50 pmBUF-DSM

8h 45m1 stop

$402Southwest

Find Deal

Mon, Jun 9 - Mon, Jun 16

5:25 am - 1:40 pmDSM-BUF

7h 15m2 stops

3:20 pm - 11:50 pmBUF-DSM

9h 30m2 stops

$407Southwest

Find Deal

Mon, Jun 9 - Mon, Jun 16

11:16 am - 4:55 pmDSM-BUF

4h 39m1 stop

8:25 am - 4:18 pmBUF-DSM

8h 53m1 stop

$437United Airlines

Find Deal

Mon, May 26 - Sat, May 31

11:16 am - 4:55 pmDSM-BUF

4h 39m1 stop

7:00 am - 10:20 amBUF-DSM

4h 20m1 stop

$438United Airlines

Find Deal

Tue, Jun 3 - Fri, Jun 6

6:57 pm - 10:24 amDSM-BUF

14h 27m1 stop

11:24 am - 6:12 pmBUF-DSM

7h 48m1 stop

$603Frontier

Find Deal

Fri, Mar 21 - Sun, Mar 23

5:00 pm - 10:58 pmDSM-BUF

4h 58m1 stop

6:00 am - 11:47 amBUF-DSM

6h 47m1 stop

$709Delta

Find Deal

Sun, Mar 16 - Sat, Mar 22

Delta flights from Des Moines to Buffalo

Our best Delta deals on Des Moines to Buffalo flight tickets

Delta

Apr 18

DSM7:15 amDes Moines

6h 03m

1 stop

BUF2:18 pmBuffalo

Apr 23

BUF6:00 amBuffalo

5h 41m

1 stop

DSM10:41 amDes Moines

$368

Find similar

Delta

Mar 16

DSM5:00 pmDes Moines

4h 58m

1 stop

BUF10:58 pmBuffalo

Mar 22

BUF6:00 amBuffalo

6h 47m

1 stop

DSM11:47 amDes Moines

$709

Find similar

Delta

Mar 16

DSM5:00 pmDes Moines

4h 58m

1 stop

BUF10:58 pmBuffalo

Mar 23

BUF6:44 pmBuffalo

5h 12m

1 stop

DSM10:56 pmDes Moines

$799

Find similar

American Airlines flights from Des Moines to Buffalo

Our best American Airlines deals on Des Moines to Buffalo flight tickets

American Airlines

Apr 18

DSM6:45 amDes Moines

6h 44m

1 stop

BUF2:29 pmBuffalo

Apr 23

BUF6:00 amBuffalo

8h 13m

2 stops

DSM1:13 pmDes Moines

$377

Find similar

American Airlines

Mar 20

DSM6:50 amDes Moines

4h 26m

1 stop

BUF12:16 pmBuffalo

Mar 27

BUF6:00 amBuffalo

8h 40m

2 stops

DSM1:40 pmDes Moines

$382

Find similar

American Airlines

Mar 20

DSM6:38 amDes Moines

7h 49m

2 stops

BUF3:27 pmBuffalo

Mar 27

BUF6:00 amBuffalo

8h 40m

2 stops

DSM1:40 pmDes Moines

$387

Find similar

How to get the cheapest flight ticket from Des Moines to Buffalo

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

Prices

Airlines

What is the cheapest day to depart on your flight to Buffalo?

Our data shows that Tuesday is the least expensive day to fly to Buffalo. Tickets to fly out on this day can be as low as $321. Flights from Des Moines to Buffalo on a Friday will generally be more expensive and average around $497. Keep in mind that these prices on both days could fluctuate depending on the season and the demand.

What is the cheapest time of day to depart on your flight to Buffalo?

In the morning is the cheapest time of day to fly from Des Moines to Buffalo when you can find flight prices for as low as $356. Flying to Buffalo in the morning is an ideal time because this is during off-peak travel hours. In the afternoon is when there is more demand to fly to Buffalo, so prices are often more expensive at around $452 per ticket.

When to book flights from Des Moines to Buffalo

Are you open to changing your travel dates? Check out the ideal times to fly from Des Moines to Buffalo according to our flight data. Find out which month and days have the cheapest flights.

Estimated round-trip price

Cheap Des Moines to Buffalo (DSM to BUF) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to Buffalo

Best Price Found	$184
Fastest flight time	3h 38m
Direct flights	None
Airports in Buffalo	1 airport

The best one-way flight to Buffalo from Des Moines in the past 72 hours is $184. The best round-trip flight deal from Des Moines to Buffalo found on momondo in the last 72 hours is $368.

The fastest flight from Des Moines to Buffalo takes 3h 38m

There are no direct flights from Des Moines to Buffalo. Popular non-direct route for this connection is Des Moines Airport - Buffalo Airport.

There is 1 airport near Buffalo: Buffalo (BUF)

Search flight deals

How far is Des Moines to Buffalo by plane?
The straight-line distance from Des Moines to Buffalo is 758.3 mi. Typically, this will take 3h 38m by plane in normal conditions.
When did momondo last update prices for flights from Des Moines Airport to Buffalo Airport?
Prices for flights from Des Moines Airport to Buffalo Airport were last updated today.
How many operators does momondo search for flights from Des Moines Airport to Buffalo Airport?
As of February 2025, there are 3 operators available to choose from for flights from Des Moines Airport to Buffalo Airport.
How old do you have to be to fly from Des Moines Airport to Buffalo Airport?
The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to Buffalo Airport.
What documentation or ID do you need to fly to Buffalo Airport?
The travel and health documents required for your trip to Buffalo Airport can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at Buffalo Airport. We always recommend checking with your airline or a trusted third party such as IATA to get advice.
What is the most popular airline from Des Moines to Buffalo?
momondo data reveals that the most frequently booked airline on the route from Des Moines to Buffalo is American Airlines, representing 43% of all bookings. The subsequent popular airlines are Delta at 42% and United Airlines at 15%.

Best airlines flying from Des Moines to Buffalo

Compare and see reviews for airlines that fly from Des Moines to Buffalo with momondo

Airline	Rating	Free Cancellation	Price
Delta	PriceFrom $196	Free Cancellation	Rating 8.0 8,219 reviews	Search Delta flights
American Airlines	PriceFrom $276	Free Cancellation	Rating 7.2 10,000 reviews	Search American Airlines flights
United Airlines	PriceFrom $357	Free Cancellation	Rating 7.4 8,765 reviews	Search United Airlines flights

Batavia

Williamsville

Amherst

Cheektowaga

Tonawanda

Lockport

West Seneca

East Aurora

Orchard Park

Grand Island

Bowmansville

Eden

Angola

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to Buffalo?

We help find the flight that best suits your needs, momondo compares prices from hundreds of airlines and travel agents and helps you filter them to find the best flight from Des Moines to Buffalo for you.

Can I find flights from Des Moines to Buffalo with flexible booking policies on momondo?

momondo does allow users to show only those flights to Buffalo from Des Moines which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Des Moines to Buffalo?

momondo provides multiple filters to help you find the best flight to Buffalo from Des Moines. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Des Moines to Buffalo right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Buffalo, momondo offers a useful price alert feature which will track prices for flights to Buffalo from Des Moines and alert you when they change.