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Cheap flights from Portland, Maine to Greenville from $152

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Portland, Maine to Greenville departing on 5/5. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Portland, Maine to Greenville

Cheap round-trip flights

KAYAK's recommended round-trip deals from the most popular airlines that fly from Portland, Maine to Greenville.
5:17 pm - 9:53 pmPWM-GSP
4h 36m1 stop
6:03 am - 10:45 amGSP-PWM
4h 42m1 stop
$297American Airlines
Find Deal
Wed, Jun 11 - Sat, Jun 14
7:41 am - 2:12 pmPWM-GSP
6h 31m2 stops
6:43 am - 11:08 amGSP-PWM
4h 25m1 stop
$302American Airlines
Find Deal
Wed, Jun 11 - Sat, Jun 14
5:40 pm - 10:00 pmPWM-GSP
4h 20m1 stop
5:40 pm - 12:05 amGSP-PWM
6h 25m1 stop
$351Southwest
Find Deal
Fri, Jun 6 - Mon, Jun 9
5:40 pm - 10:00 pmPWM-GSP
4h 20m1 stop
5:45 am - 4:55 pmGSP-PWM
11h 10m2 stops
$382Southwest
Find Deal
Fri, Jun 6 - Mon, Jun 9
5:18 pm - 9:49 pmPWM-GSP
4h 31m1 stop
7:00 am - 2:02 pmGSP-PWM
7h 02m1 stop
$411American Airlines
Find Deal
Fri, May 2 - Sun, May 4
1:53 pm - 11:55 pmPWM-GSP
10h 02m2 stops
2:56 pm - 12:46 amGSP-PWM
9h 50m2 stops
$463Delta
Find Deal
Wed, Jun 11 - Sat, Jun 14
4:15 pm - 10:37 pmPWM-GSP
6h 22m1 stop
6:50 am - 2:53 pmGSP-PWM
8h 03m1 stop
$544United Airlines
Find Deal
Mon, Apr 21 - Wed, Apr 23
4:15 pm - 10:37 pmPWM-GSP
6h 22m1 stop
6:50 am - 5:22 pmGSP-PWM
10h 32m2 stops
$549United Airlines
Find Deal
Mon, Apr 21 - Wed, Apr 23
12:00 pm - 9:23 amPWM-GSP
21h 23m2 stops
2:29 pm - 5:10 pmGSP-PWM
26h 41m3 stops
$1,490Breeze Airways
Find Deal
Wed, Apr 23 - Sun, Apr 27
6:18 pm - 9:23 amPWM-GSP
39h 05m2 stops
2:29 pm - 5:10 pmGSP-PWM
26h 41m3 stops
$2,019Breeze Airways
Find Deal
Fri, Apr 18 - Sun, Apr 20

Southwest flights from Portland, Maine to Greenville

Our best Southwest deals on Portland, Maine to Greenville flight tickets
Southwest
Jun 6
PWM5:40 pmPortland
4h 20m
1 stop
GSP10:00 pmGreenville
Jun 9
GSP5:40 pmGreenville
6h 25m
1 stop
PWM12:05 amPortland
Southwest
Jun 6
PWM5:40 pmPortland
4h 20m
1 stop
GSP10:00 pmGreenville
Jun 9
GSP5:45 amGreenville
11h 10m
2 stops
PWM4:55 pmPortland
Southwest
Jun 6
PWM7:40 pmPortland
17h 45m
2 stops
GSP1:25 pmGreenville
Jun 9
GSP5:45 amGreenville
11h 10m
2 stops
PWM4:55 pmPortland

American Airlines flights from Portland, Maine to Greenville

Our best American Airlines deals on Portland, Maine to Greenville flight tickets
American Airlines
Jun 11
PWM5:17 pmPortland
4h 36m
1 stop
GSP9:53 pmGreenville
Jun 14
GSP6:03 amGreenville
4h 42m
1 stop
PWM10:45 amPortland
American Airlines
Jun 11
PWM7:41 amPortland
6h 31m
2 stops
GSP2:12 pmGreenville
Jun 14
GSP6:43 amGreenville
4h 25m
1 stop
PWM11:08 amPortland
American Airlines
Apr 15
PWM12:15 pmPortland
10h 24m
1 stop
GSP10:39 pmGreenville
Apr 19
GSP7:00 amGreenville
4h 24m
1 stop
PWM11:24 amPortland

See travel insights to Greenville from

How to get the cheapest flight ticket from Portland, Maine to Greenville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to Greenville?

The month of September is another great option to travel to Greenville, with average flight prices from Portland, Maine averaging around $336.

What is the cheapest day to depart on your flight to Greenville?

According to our data, Tuesday is the cheapest day to fly to Greenville from Portland, Maine. The lowest ticket price found for a Tuesday departure recently was $371. Keep in mind that prices can always vary depending on your route and whether or not you are flying domestic or international. If your travel schedule is flexible, try to avoid departing on a Sunday because tickets tend to average around $610. These prices are subject to change though, so be sure to set up a Price Alert for flights to Greenville.

What is the cheapest time of day to depart on your flight to Greenville?

Our most recent data shows that the best time of day to fly to Greenville is in the afternoon. Flights from Portland, Maine to Greenville during this time can be as low as $371. Flights to Greenville are more costly in the morning, with an average ticket price of $415. Departure times in the morning fall within the peak daily travel times, which is why tickets can be more expensive.

How have Portland, Maine to Greenville flight prices changed over time?

As of April 2025, prices for Portland, Maine to Greenville flights are approximately 9% cheaper when compared to flights at the same time last year.

When to book flights from Portland, Maine to Greenville

Are you open to changing your travel dates? Check out the ideal times to fly from Portland, Maine to Greenville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Portland, Maine to Greenville (PWM to GSP) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Portland, Maine to Greenville

Best Price Found

$152

Fastest flight time

3h 53m

Direct flights

None

Airports in Greenville

1 airport
The best one-way flight to Greenville from Portland, Maine in the past 72 hours is $152. The best round-trip flight deal from Portland, Maine to Greenville found on momondo in the last 72 hours is $297.
The fastest flight from Portland, Maine to Greenville takes 3h 53m
There are no direct flights from Portland, Maine to Greenville. Popular non-direct route for this connection is Portland Airport - Greenville Airport.
There is 1 airport near Greenville: Greenville (GSP)

  • How far is Portland to Greenville by plane?

    Portland and Greenville are 887.7 mi apart from one another. 3h 53m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Portland Airport to Greenville Airport?

    Prices for flights from Portland Airport to Greenville Airport refresh daily.

  • How many operators does momondo search for flights from Portland Airport to Greenville Airport?

  • How old do you have to be to fly from Portland Airport to Greenville Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Portland Airport to Greenville Airport.

  • What documentation or ID do you need to fly to Greenville Airport?

    The required travel and health documents for your Greenville Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Greenville Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Portland, Maine to Greenville?


Best airlines flying from Portland, Maine to Greenville

Compare and see reviews for airlines that fly from Portland, Maine to Greenville with momondo
Airline
Rating
Free Cancellation
Price
American AirlinesPriceFrom $276Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
SouthwestPriceFrom $301Free CancellationRating
8.0
4,277 reviews
Search Southwest flights
DeltaPriceFrom $315Free CancellationRating
8.0
7,899 reviews
Search Delta flights

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Anderson
Simpsonville
Greenwood
Seneca
Greer
Duncan

Why use momondo?

Why should I use momondo to find a flight deal from Portland to Greenville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Portland to Greenville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Portland to Greenville with flexible booking policies on momondo?

momondo does allow users to show only those flights to Greenville from Portland which offer a flexible booking policy as well as other useful filters and features.

How can momondo help me find flights from Portland to Greenville?

momondo offers useful filters to help you find the right flight. Choose specific flight times, airports or even what payment method you prefer. We have numerous options to help you book your ideal flight from Portland to Greenville.

I’m not ready to book a flight from Portland to Greenville right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Portland to Greenville flights. All you need is a valid email address and we will do the rest; it is that quick and easy.


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