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Cheap flights from Knoxville to St. Louis from $228

This is the cheapest round-trip flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to St. Louis departing on 2/1. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to St. Louis

Cheap round-trip flights

These are some of the best round-trip flight deals from Knoxville to St. Louis that have been recently found on momondo from popular airlines, departing in the coming months.

Cheap one-way flights

Flying one-way? These are some of the best deals recently discovered on momondo for flights from Knoxville to St. Louis.

Cheap last minute flights

Planning a quick getaway from Knoxville to St. Louis? These are the last-minute flight deals available now.

Cheap direct flights

If you prefer a non-stop journey, check out our latest direct flight deals to St. Louis, so you can enjoy a seamless trip without layovers.

Cheap bus & train deals from Knoxville to St. Louis

Find recent round-trip train or bus tickets from Knoxville to St. Louis.

All round-trip flight deals to St. Louis

The cheapest plane tickets to St. Louis found on KAYAK recently.
2:07 pm - 6:45 pmTYS-STL
5h 38m1 stop
5:29 pm - 10:22 pmSTL-TYS
3h 53m1 stop
$228Delta
Find Deal
Sat, Feb 1 - Sat, Feb 8
4:08 pm - 10:26 pmTYS-STL
7h 18m2 stops
5:03 am - 11:26 amSTL-TYS
5h 23m1 stop
$233American Airlines
Find Deal
Sat, Feb 1 - Sat, Feb 8
11:30 am - 5:20 pmTYS-STL
6h 50m1 stop
2:03 pm - 8:50 pmSTL-TYS
5h 47m1 stop
$418American Airlines
Find Deal
Mon, May 5 - Fri, May 9
5:45 am - 8:02 pmTYS-STL
15h 17m2 stops
2:55 pm - 2:43 pmSTL-TYS
22h 48m2 stops
$435United Airlines
Find Deal
Sat, Feb 1 - Sat, Feb 8
5:55 pm - 6:41 pmTYS-STL
25h 46m3 stops
4:28 pm - 2:28 pmSTL-TYS
21h 00m2 stops
Sun, Jan 5 - Thu, Jan 9
7:25 pm - 12:12 pmTYS-STL
17h 47m2 stops
5:36 pm - 11:00 pmSTL-TYS
4h 24m1 stop
$452United Airlines
Find Deal
Fri, Feb 28 - Sun, Mar 2
6:46 pm - 6:41 pmTYS-STL
24h 55m3 stops
4:28 pm - 2:00 pmSTL-TYS
20h 32m3 stops
Sun, Jan 5 - Thu, Jan 9
6:55 am - 10:47 amTYS-STL
4h 52m1 stop
6:30 am - 1:18 pmSTL-TYS
5h 48m1 stop
$558United Airlines
Find Deal
Sun, Jan 5 - Thu, Jan 9
7:00 am - 12:19 pmTYS-STL
6h 19m1 stop
5:31 pm - 2:46 pmSTL-TYS
20h 15m2 stops
$588United Airlines
Find Deal
Mon, May 5 - Fri, May 9
6:55 am - 10:47 amTYS-STL
4h 52m1 stop
6:30 am - 2:43 pmSTL-TYS
7h 13m2 stops
$661United Airlines
Find Deal
Sun, Jan 5 - Thu, Jan 9
6:50 pm - 10:43 pmTYS-STL
4h 53m1 stop
$352American Airlines
Find Deal
Sat, Jan 4
6:55 am - 8:23 pmTYS-STL
14h 28m2 stops
$818United Airlines
Find Deal
Sat, Jan 4
6:55 am - 8:23 pmTYS-STL
14h 28m2 stops
$944United Airlines
Find Deal
Sat, Jan 4
6:41 pm - 10:28 pmTYS-STL
4h 47m1 stop
7:30 am - 2:06 pmSTL-TYS
5h 36m1 stop
$353American Airlines
Find Deal
Thu, Dec 26 - Thu, Jan 2
6:55 am - 10:47 amTYS-STL
4h 52m1 stop
5:00 am - 10:05 amSTL-TYS
4h 05m1 stop
$493United Airlines
Find Deal
Wed, Dec 25 - Fri, Dec 27
6:55 am - 10:47 amTYS-STL
4h 52m1 stop
6:00 am - 10:38 pmSTL-TYS
15h 38m2 stops
$787United Airlines
Find Deal
Thu, Dec 26 - Thu, Jan 2
6:55 am - 10:47 amTYS-STL
4h 52m1 stop
5:00 am - 7:22 pmSTL-TYS
13h 22m2 stops
$793United Airlines
Find Deal
Wed, Dec 25 - Fri, Dec 27
6:55 am - 4:47 pmTYS-STL
10h 52m2 stops
6:00 am - 4:54 pmSTL-TYS
9h 54m2 stops
$2,195United Airlines
Find Deal
Wed, Dec 25 - Fri, Dec 27
6:55 am - 4:47 pmTYS-STL
10h 52m2 stops
11:10 am - 8:48 pmSTL-TYS
8h 38m2 stops
$2,466United Airlines
Find Deal
Thu, Dec 26 - Thu, Jan 2

United Airlines flights from Knoxville to St. Louis

Our best United Airlines deals on Knoxville to St. Louis flight tickets
United Airlines
Feb 1
TYS5:45 amKnoxville McGhee Tyson
15h 17m
2 stops
STL8:02 pmLambert-St Louis
Feb 8
STL2:55 pmLambert-St Louis
22h 48m
2 stops
TYS2:43 pmKnoxville McGhee Tyson
United Airlines
Feb 28
TYS7:25 pmKnoxville McGhee Tyson
17h 47m
2 stops
STL12:12 pmLambert-St Louis
Mar 2
STL5:36 pmLambert-St Louis
4h 24m
1 stop
TYS11:00 pmKnoxville McGhee Tyson
United Airlines
Dec 25
TYS6:55 amKnoxville McGhee Tyson
4h 52m
1 stop
STL10:47 amLambert-St Louis
Dec 27
STL5:00 amLambert-St Louis
4h 05m
1 stop
TYS10:05 amKnoxville McGhee Tyson

American Airlines flights from Knoxville to St. Louis

Our best American Airlines deals on Knoxville to St. Louis flight tickets
American Airlines
Feb 1
TYS4:08 pmKnoxville McGhee Tyson
7h 18m
2 stops
STL10:26 pmLambert-St Louis
Feb 8
STL5:03 amLambert-St Louis
5h 23m
1 stop
TYS11:26 amKnoxville McGhee Tyson
American Airlines
Dec 30
TYS6:34 amKnoxville McGhee Tyson
5h 35m
1 stop
STL11:09 amLambert-St Louis
Jan 1
STL10:16 amLambert-St Louis
6h 55m
1 stop
TYS6:11 pmKnoxville McGhee Tyson
American Airlines
Dec 26
TYS6:41 pmKnoxville McGhee Tyson
4h 47m
1 stop
STL10:28 pmLambert-St Louis
Jan 2
STL7:30 amLambert-St Louis
5h 36m
1 stop
TYS2:06 pmKnoxville McGhee Tyson

See travel insights to St. Louis from

How to get the cheapest flight ticket from Knoxville to St. Louis

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to St. Louis?

In general, April is the cheapest month to fly from Knoxville to St. Louis. Due to it being the ‘off-season’ during this time, you can expect flight prices to be around $254. The month of September is another great option to travel to St. Louis, with average flight prices from Knoxville averaging around $261.

What is the cheapest day to depart on your flight to St. Louis?

The cheapest day to depart on your flight to St. Louis is on a Wednesday when prices can be found for as low as $259. This is often the case because there is less demand to fly during this day of the week. If your travel schedule is flexible, try to avoid departing on a Monday because tickets tend to average around $539. These prices are subject to change though, so be sure to set up a Price Alert for flights to St. Louis.

What is the cheapest time of day to depart on your flight to St. Louis?

Flying to St. Louis from Knoxville at noon is the least expensive time of day to depart. momondo users have found prices as low as $265 when looking at flights departing at noon. In the morning is when there is more demand to fly to St. Louis, so prices are often more expensive at around $288 per ticket.

How have Knoxville to St. Louis flight prices changed over time?

As of December 2024, prices for Knoxville to St. Louis flights are approximately 32% more expensive when compared to flights at the same time last year.

When to book flights from Knoxville to St. Louis

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to St. Louis according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to St. Louis (TYS to STL) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to St. Louis

Best Price Found

$352

Fastest flight time

4h 52m

Direct flights

None

Airports in St. Louis

1 airport
The best one-way flight to St. Louis from Knoxville in the past 72 hours is $352. The best round-trip flight deal from Knoxville to St. Louis found on momondo in the last 72 hours is $228.
The fastest flight from Knoxville to St. Louis takes 4h 52m
There are no direct flights from Knoxville to St. Louis. Popular non-direct route for this connection is Knoxville McGhee Tyson Airport - Lambert-St Louis Airport.
There is 1 airport near St. Louis: Lambert-St Louis (STL)

  • How far is Knoxville McGhee Tyson to Lambert-St Louis by plane?

    Lambert-St Louis is 390.7 mi away from Knoxville McGhee Tyson. By plane, this route typically takes 4h 52m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport are updated daily.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Knoxville McGhee Tyson Airport to Lambert-St Louis Airport.

  • What documentation or ID do you need to fly to Lambert-St Louis Airport?

    The required travel and health documents for your Lambert-St Louis Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Lambert-St Louis Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular airline from Knoxville to St. Louis?


Best airlines flying from Knoxville to St. Louis

Compare and see reviews for airlines that fly from Knoxville to St. Louis with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $213Free CancellationRating
8.0
8,594 reviews
Search Delta flights
American AirlinesPriceFrom $213Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $240Free CancellationRating
7.4
9,028 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to St. Louis?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Knoxville to St. Louis. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Knoxville to St. Louis with flexible booking policies on momondo?

Yes. All flights to St. Louis from Knoxville on momondo can be compared and filtered by various policies on offer, including flexible booking.

How can momondo help me find flights from Knoxville to St. Louis?

momondo provides multiple filters to help you find the best flight to St. Louis from Knoxville. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Knoxville to St. Louis right now. Can momondo alert me if prices change?

If you are not ready to book a flight from Knoxville to St. Louis now, use our insights above to find helpful tips or alternatively set up a price alert, where momondo will track prices on flights to St. Louis and let you know when they change.


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