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Cheap flights from Knoxville to Des Moines from $264

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Knoxville to Des Moines departing on 12/4. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Knoxville to Des Moines

Cheap round-trip flights

These are some of the best round-trip flight deals from Knoxville to Des Moines that have been recently found on momondo from popular airlines, departing in the coming months.

Cheap one-way flights

Flying one-way? These are some of the best deals recently discovered on momondo for flights from Knoxville to Des Moines.

Cheap last minute flights

Planning a quick getaway from Knoxville to Des Moines? These are the last-minute flight deals available now.

Cheap direct flights

If you prefer a non-stop journey, check out our latest direct flight deals to Des Moines, so you can enjoy a seamless trip without layovers.

Cheap bus & train deals from Knoxville to Des Moines

Find recent round-trip train or bus tickets from Knoxville to Des Moines.

All round-trip flight deals to Des Moines

The cheapest plane tickets to Des Moines found on KAYAK recently.
5:35 pm - 9:52 pmTYS-DSM
5h 17m1 stop
8:00 am - 8:48 pmDSM-TYS
11h 48m1 stop
$483United Airlines
Find Deal
Wed, Dec 25 - Sat, Dec 28
9:10 am - 5:54 pmTYS-DSM
9h 44m2 stops
8:00 am - 8:48 pmDSM-TYS
11h 48m1 stop
$488United Airlines
Find Deal
Wed, Dec 25 - Sat, Dec 28
8:00 am - 6:13 pmTYS-DSM
11h 13m1 stop
7:00 am - 10:22 pmDSM-TYS
14h 22m1 stop
$507Allegiant Air
Find Deal
Mon, Dec 2 - Fri, Dec 6
7:05 am - 3:14 pmTYS-DSM
9h 09m2 stops
5:39 pm - 12:20 amDSM-TYS
5h 41m1 stop
$523American Airlines
Find Deal
Thu, Dec 26 - Sun, Dec 29
7:23 pm - 11:57 pmTYS-DSM
5h 34m1 stop
12:23 pm - 9:09 pmDSM-TYS
7h 46m2 stops
$539American Airlines
Find Deal
Mon, Dec 2 - Fri, Dec 6
5:35 pm - 9:52 pmTYS-DSM
5h 17m1 stop
8:00 am - 8:48 pmDSM-TYS
11h 48m1 stop
$549United Airlines
Find Deal
Thu, Dec 26 - Sun, Dec 29
5:35 pm - 9:52 pmTYS-DSM
5h 17m1 stop
6:40 pm - 4:54 pmDSM-TYS
21h 14m1 stop
$568United Airlines
Find Deal
Fri, Dec 27 - Mon, Dec 30
7:05 am - 3:14 pmTYS-DSM
9h 09m2 stops
11:58 am - 9:30 pmDSM-TYS
8h 32m2 stops
$598American Airlines
Find Deal
Thu, Dec 26 - Sun, Dec 29
5:35 pm - 9:52 pmTYS-DSM
5h 17m1 stop
8:00 am - 7:22 pmDSM-TYS
10h 22m2 stops
$623United Airlines
Find Deal
Fri, Dec 27 - Mon, Dec 30
2:32 pm - 8:55 pmTYS-DSM
7h 23m2 stops
6:55 am - 3:05 pmDSM-TYS
7h 10m2 stops
$2,223Delta
Find Deal
Fri, Dec 27 - Mon, Dec 30
8:15 am - 9:58 pmTYS-DSM
38h 43m3 stops
Wed, Dec 4
7:03 am - 1:40 pmTYS-DSM
7h 37m1 stop
$267American Airlines
Find Deal
Wed, Dec 4
10:46 am - 4:20 pmTYS-DSM
6h 34m2 stops
$272American Airlines
Find Deal
Wed, Dec 4

United Airlines flights from Knoxville to Des Moines

Our best United Airlines deals on Knoxville to Des Moines flight tickets
United Airlines
Dec 25
TYS5:35 pmKnoxville McGhee Tyson
5h 17m
1 stop
DSM9:52 pmDes Moines
Dec 28
DSM8:00 amDes Moines
11h 48m
1 stop
TYS8:48 pmKnoxville McGhee Tyson
United Airlines
Dec 25
TYS9:10 amKnoxville McGhee Tyson
9h 44m
2 stops
DSM5:54 pmDes Moines
Dec 28
DSM8:00 amDes Moines
11h 48m
1 stop
TYS8:48 pmKnoxville McGhee Tyson
United Airlines
Nov 26
TYS7:00 amKnoxville McGhee Tyson
4h 29m
1 stop
DSM10:29 amDes Moines
Dec 1
DSM9:34 pmDes Moines
23h 50m
1 stop
TYS10:24 pmKnoxville McGhee Tyson

American Airlines flights from Knoxville to Des Moines

Our best American Airlines deals on Knoxville to Des Moines flight tickets
American Airlines
Nov 26
TYS6:00 amKnoxville McGhee Tyson
6h 59m
1 stop
DSM11:59 amDes Moines
Nov 30
DSM6:55 amDes Moines
5h 01m
1 stop
TYS12:56 pmKnoxville McGhee Tyson
American Airlines
Nov 26
TYS5:00 amKnoxville McGhee Tyson
7h 07m
2 stops
DSM11:07 amDes Moines
Nov 30
DSM6:55 amDes Moines
5h 01m
1 stop
TYS12:56 pmKnoxville McGhee Tyson
American Airlines
Dec 26
TYS7:05 amKnoxville McGhee Tyson
9h 09m
2 stops
DSM3:14 pmDes Moines
Dec 29
DSM5:39 pmDes Moines
5h 41m
1 stop
TYS12:20 amKnoxville McGhee Tyson

How to get the cheapest flight ticket from Knoxville to Des Moines

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly from Knoxville to Des Moines?

August. The cheapest time of year to fly to Des Moines from Knoxville is August. Most expensive is February

What is the cheapest day to depart Knoxville for Des Moines?

Thursday. The cheapest day of the week is typically Thursday. The most expensive is typically Monday

When is the cheapest time to fly from Knoxville to Des Moines?

In the morning. Knoxville to Des Moines flights are approximately 6% more expensive in the evening than in the morning

What is the cheapest airline that flies to Des Moines from Knoxville?

American Airlines. American Airlines, Delta, and United Airlines are the most popular carriers operating from Knoxville to Des Moines

What is the cheapest Knoxville to Des Moines flight route?

Knoxville McGhee Tyson - Des Moines. Fly from Knoxville McGhee Tyson to Des Moines for the best Knoxville - Des Moines flight prices

When to book flights from Knoxville to Des Moines

Are you open to changing your travel dates? Check out the ideal times to fly from Knoxville to Des Moines according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Knoxville to Des Moines (TYS to DSM) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Knoxville to Des Moines

Best Price Found

$264

Fastest flight time

5h 17m

Direct flights

None

Airports in Des Moines

1 airport
The best one-way flight to Des Moines from Knoxville in the past 72 hours is $264. The best round-trip flight deal from Knoxville to Des Moines found on momondo in the last 72 hours is $483.
The fastest flight from Knoxville to Des Moines takes 5h 17m
There are no direct flights from Knoxville to Des Moines. Popular non-direct route for this connection is Knoxville McGhee Tyson Airport - Des Moines Airport.
There is 1 airport near Des Moines: Des Moines (DSM)

  • How far is Knoxville McGhee Tyson to Des Moines by plane?

    There are 650.4 mi between Knoxville McGhee Tyson and Des Moines. A reasonable flight in good conditions will take 5h 17m.

  • When did momondo last update prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

    Prices for flights from Knoxville McGhee Tyson Airport to Des Moines Airport were last updated today.

  • How many operators does momondo search for flights from Knoxville McGhee Tyson Airport to Des Moines Airport?

  • How old do you have to be to fly from Knoxville McGhee Tyson Airport to Des Moines Airport?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Knoxville McGhee Tyson Airport to Des Moines Airport.

  • What documentation or ID do you need to fly to Des Moines Airport?

    The necessary travel and health documents for your Des Moines Airport trip may vary depending on your travel plans and individual circumstances. Generally, you should have various documents, such as a national ID card or driver's license and a passport that is valid for six months beyond your scheduled arrival date. We recommend seeking advice from your airline or a trusted third party, such as IATA.

  • What is the most popular airline from Knoxville to Des Moines?


Best airlines flying from Knoxville to Des Moines

Compare and see reviews for airlines that fly from Knoxville to Des Moines with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $212Free CancellationRating
8.0
8,766 reviews
Search Delta flights
American AirlinesPriceFrom $248Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $252Free CancellationRating
7.4
9,168 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Knoxville to Des Moines?

momondo collates all your flight options in one place and lets you filter them to find the perfect flight from Knoxville to Des Moines. momondo saves you time and could save you money on your trip.

Can I find flights from Knoxville to Des Moines with flexible booking policies on momondo?

Flights from Knoxville to Des Moines with flexible booking policies can be found by using the search form above and then selecting our dedicated flexible booking filter, which will highlight only the flights where this policy is applied.

How can momondo help me find flights from Knoxville to Des Moines?

Once all potential Knoxville to Des Moines flight options are in front of you, momondo lets you sort and filter flights based on preferences such as airline, price and flight times amongst many other options.

I’m not ready to book a flight from Knoxville to Des Moines right now. Can momondo alert me if prices change?

If you are simply researching potential flights to Des Moines, momondo offers a useful price alert feature which will track prices for flights to Des Moines from Knoxville and alert you when they change.


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