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Cheap flights from Des Moines to South Carolina from $61

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Des Moines to South Carolina departing on 2/24. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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Find the cheapest flights from Des Moines to South Carolina

Cheap round-trip flights

These are some of the best round-trip flight deals from Des Moines to South Carolina that have been recently found on momondo from popular airlines, departing in the coming months.

Cheap one-way flights

Flying one-way? These are some of the best deals recently discovered on momondo for flights from Des Moines to South Carolina.

Cheap last minute flights

Planning a quick getaway from Des Moines to South Carolina? These are the last-minute flight deals available now.

Cheap direct flights

If you prefer a non-stop journey, check out our latest direct flight deals to South Carolina, so you can enjoy a seamless trip without layovers.

Cheap bus & train deals from Des Moines to South Carolina

Find recent round-trip train or bus tickets from Des Moines to South Carolina.

All round-trip flight deals from Des Moines to South Carolina

The cheapest plane tickets from Des Moines to South Carolina found on KAYAK recently.
7:17 pm - 7:08 amDSM-CLT
10h 51m1 stop
7:57 pm - 7:41 pmCLT-DSM
24h 44m1 stop
$178Frontier
Find Deal
Mon, Feb 17 - Thu, Feb 20
7:17 pm - 7:08 amDSM-CLT
10h 51m1 stop
7:57 pm - 7:41 pmCLT-DSM
24h 44m1 stop
$220Frontier
Find Deal
Fri, Feb 21 - Thu, Feb 27
7:00 am - 11:41 pmDSM-CLT
15h 41m1 stop
9:38 pm - 1:34 pmCLT-DSM
16h 56m1 stop
Mon, Feb 24 - Tue, Feb 25
3:29 pm - 3:13 pmDSM-CLT
22h 44m2 stops
9:38 pm - 1:34 pmCLT-DSM
16h 56m1 stop
Mon, Feb 24 - Tue, Feb 25
2:14 pm - 9:51 pmDSM-CAE
6h 37m1 stop
5:40 am - 10:16 amCAE-DSM
5h 36m1 stop
$249Delta
Find Deal
Fri, Apr 25 - Tue, Apr 29
2:14 pm - 9:51 pmDSM-CAE
6h 37m1 stop
5:40 am - 11:26 amCAE-DSM
6h 46m2 stops
$254Delta
Find Deal
Fri, Apr 25 - Tue, Apr 29
6:35 am - 12:16 pmDSM-CHS
4h 41m1 stop
5:16 pm - 10:57 pmCHS-DSM
6h 41m1 stop
$257American Airlines
Find Deal
Mon, Feb 17 - Thu, Feb 20
2:06 pm - 10:02 pmDSM-CHS
6h 56m1 stop
5:18 am - 12:21 pmCHS-DSM
8h 03m2 stops
$262American Airlines
Find Deal
Mon, Feb 17 - Thu, Feb 20
3:34 pm - 9:29 pmDSM-SAV
4h 55m1 stop
5:05 pm - 9:52 pmSAV-DSM
5h 47m1 stop
$327United Airlines
Find Deal
Wed, Apr 2 - Thu, Apr 17
11:38 am - 11:59 pmDSM-SAV
11h 21m2 stops
5:05 pm - 9:52 pmSAV-DSM
5h 47m1 stop
$332United Airlines
Find Deal
Wed, Apr 2 - Wed, Apr 16
7:17 pm - 7:08 amDSM-CLT
10h 51m1 stop
$61Frontier
Find Deal
Mon, Feb 24
7:17 pm - 7:08 amDSM-CLT
10h 51m1 stop
$91Frontier
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Fri, Feb 21
2:14 pm - 8:41 pmDSM-CHS
5h 27m1 stop
$129Delta
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Mon, Apr 28
7:00 am - 10:20 amDSM-CLT
2h 20mnonstop
$163American Airlines
Find Deal
Wed, Apr 23
7:07 am - 5:36 pmDSM-HHH
9h 29m2 stops
$164American Airlines
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Wed, Apr 30
10:32 am - 3:56 pmDSM-CLT
4h 24m1 stop
$173Delta
Find Deal
Thu, Feb 20
6:40 am - 5:50 pmDSM-CLT
10h 10m2 stops
$178Southwest
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Wed, Apr 23
7:00 am - 6:20 pmDSM-CHS
10h 20m2 stops
$189Southwest
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Mon, Apr 28
3:34 pm - 9:38 pmDSM-CLT
5h 04m1 stop
$208United Airlines
Find Deal
Mon, Apr 21
11:29 am - 9:29 pmDSM-CLT
9h 00m2 stops
$213United Airlines
Find Deal
Thu, Feb 20
6:00 pm - 8:15 amDSM-CLT
13h 15m1 stop
12:06 pm - 1:36 pmCLT-DSM
2h 30mnonstop
$369American Airlines
Find Deal
Sat, Jan 25 - Sun, Jan 26
3:28 pm - 9:21 pmDSM-CAE
4h 53m1 stop
6:15 am - 4:11 pmCAE-DSM
10h 56m2 stops
$409United Airlines
Find Deal
Fri, Jan 24 - Sat, Feb 1
8:00 am - 7:34 pmDSM-CAE
10h 34m2 stops
6:15 am - 4:11 pmCAE-DSM
10h 56m2 stops
$435United Airlines
Find Deal
Fri, Jan 24 - Sat, Feb 1
5:33 am - 1:32 pmDSM-CLT
6h 59m1 stop
12:49 pm - 5:36 pmCLT-DSM
5h 47m1 stop
$462Delta
Find Deal
Fri, Jan 24 - Wed, Feb 5
3:28 pm - 9:21 pmDSM-CAE
4h 53m1 stop
6:15 am - 10:38 amCAE-DSM
5h 23m1 stop
$464United Airlines
Find Deal
Fri, Jan 24 - Sat, Feb 1
6:30 am - 12:40 pmDSM-CLT
5h 10m1 stop
6:05 pm - 9:30 pmCLT-DSM
4h 25m1 stop
$469Southwest
Find Deal
Tue, Jan 28 - Thu, Jan 30
6:30 am - 12:40 pmDSM-CLT
5h 10m1 stop
6:20 am - 7:00 pmCLT-DSM
13h 40m2 stops
$474Southwest
Find Deal
Fri, Jan 24 - Wed, Feb 5
8:30 am - 7:45 pmDSM-CLT
10h 15m2 stops
6:20 am - 7:00 pmCLT-DSM
13h 40m2 stops
$479Southwest
Find Deal
Fri, Jan 24 - Wed, Feb 5
6:17 am - 9:38 amDSM-CLT
2h 21mnonstop
8:29 pm - 10:05 pmCLT-DSM
2h 36mnonstop
$535American Airlines
Find Deal
Sat, Jan 25 - Mon, Jan 27
5:33 am - 11:09 amDSM-CLT
4h 36m1 stop
6:02 am - 11:35 amCLT-DSM
6h 33m1 stop
$581Delta
Find Deal
Sun, Jan 26 - Sun, Feb 2
6:35 am - 9:57 amDSM-CLT
2h 22mnonstop
11:58 am - 1:28 pmCLT-DSM
2h 30mnonstop
$325American Airlines
Find Deal
Tue, Feb 18 - Tue, Feb 25
2:06 pm - 5:30 pmDSM-CLT
2h 24mnonstop
11:58 am - 1:28 pmCLT-DSM
2h 30mnonstop
$345American Airlines
Find Deal
Mon, Feb 17 - Fri, Feb 21
2:09 pm - 5:30 pmDSM-CLT
2h 21mnonstop
8:10 pm - 9:30 pmCLT-DSM
2h 20mnonstop
$349American Airlines
Find Deal
Tue, May 20 - Sat, May 24
6:40 am - 9:56 amDSM-CLT
2h 16mnonstop
11:59 am - 1:13 pmCLT-DSM
2h 14mnonstop
$362American Airlines
Find Deal
Thu, Apr 3 - Sun, Apr 6
2:06 pm - 5:30 pmDSM-CLT
2h 24mnonstop
12:11 pm - 1:40 pmCLT-DSM
2h 29mnonstop
$365American Airlines
Find Deal
Sat, Mar 8 - Sat, Mar 15
10:24 am - 1:35 pmDSM-CLT
2h 11mnonstop
12:11 pm - 1:40 pmCLT-DSM
2h 29mnonstop
$368American Airlines
Find Deal
Sat, Mar 8 - Sat, Mar 15
7:00 am - 10:20 amDSM-CLT
2h 20mnonstop
11:59 am - 1:13 pmCLT-DSM
2h 14mnonstop
$382American Airlines
Find Deal
Fri, Apr 4 - Sun, Apr 6
7:09 am - 10:30 amDSM-CLT
2h 21mnonstop
10:33 pm - 12:05 amCLT-DSM
2h 32mnonstop
$386American Airlines
Find Deal
Thu, Jun 19 - Tue, Jun 24
2:06 pm - 5:30 pmDSM-CLT
2h 24mnonstop
11:58 am - 1:28 pmCLT-DSM
2h 30mnonstop
$388American Airlines
Find Deal
Fri, Feb 21 - Sun, Feb 23
4:18 pm - 7:40 pmDSM-CLT
2h 22mnonstop
1:00 pm - 2:23 pmCLT-DSM
2h 23mnonstop
$392American Airlines
Find Deal
Sat, Jun 21 - Mon, Jun 23

Frontier flights from Des Moines to South Carolina

Our best Frontier deals on Des Moines to South Carolina flight tickets
Frontier
Feb 17
DSM7:17 pmDes Moines
10h 51m
1 stop
CLT7:08 amCharlotte Douglas
Feb 20
CLT7:57 pmCharlotte Douglas
24h 44m
1 stop
DSM7:41 pmDes Moines
Frontier
Feb 21
DSM7:17 pmDes Moines
10h 51m
1 stop
CLT7:08 amCharlotte Douglas
Feb 27
CLT7:57 pmCharlotte Douglas
24h 44m
1 stop
DSM7:41 pmDes Moines
Frontier
Apr 4
DSM8:17 pmDes Moines
21h 40m
1 stop
CLT6:57 pmCharlotte Douglas
Apr 6
CLT10:20 pmCharlotte Douglas
21h 59m
1 stop
DSM7:19 pmDes Moines

Southwest flights from Des Moines to South Carolina

Our best Southwest deals on Des Moines to South Carolina flight tickets
Southwest
Apr 15
DSM5:40 amDes Moines
10h 35m
2 stops
MYR5:15 pmMyrtle Beach Intl
Apr 22
MYR11:00 amMyrtle Beach Intl
9h 55m
2 stops
DSM7:55 pmDes Moines
Southwest
Feb 18
DSM6:10 amDes Moines
11h 15m
2 stops
CLT6:25 pmCharlotte Douglas
Feb 25
CLT6:05 pmCharlotte Douglas
4h 25m
1 stop
DSM9:30 pmDes Moines
Southwest
Feb 18
DSM6:10 amDes Moines
13h 15m
2 stops
CLT8:25 pmCharlotte Douglas
Feb 25
CLT11:05 amCharlotte Douglas
11h 25m
2 stops
DSM9:30 pmDes Moines

See travel insights to South Carolina from

How to get the cheapest flight ticket from Des Moines to South Carolina

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the cheapest month to fly to South Carolina?

The cheapest month to fly to South Carolina from Des Moines is in September. Flight prices, which tend to average around $341, are often lower during this time because this is during the off-season. If you aren’t able to travel during the month of September, then book flights to South Carolina from Des Moines during October instead. Flights to South Carolina in October, while not as cheap as those in September, still average around $362.

What is the cheapest day to depart on your flight to South Carolina?

Our data shows that Monday is the least expensive day to fly to South Carolina. Tickets to fly out on this day can be as low as $379. The most expensive day to fly to South Carolina is Thursday, with ticket prices averaging around $508.

What is the cheapest time of day to depart on your flight to South Carolina?

Our data shows that the cheapest Des Moines to South Carolina flights are usually those with departure times in the afternoon. Our users have found flights to South Carolina in the afternoon for as low as $386. Try not to purchase tickets in the morning because they tend to be around $405. Of course, these prices can vary depending on the time of year and what airport you fly to.

How far in advance should I book a flight to South Carolina?

You are more likely to see cheaper flights to South Carolina from Des Moines when booking 21 weeks ahead of your departure date. In general, you can expect to find flights to South Carolina for around $398 when searching 21 weeks out.However, flight prices might be lower outside of this timeframe. For example, people recently found flights to South Carolina from Des Moines for as low as $291 on momondo.

Cheap Des Moines to South Carolina flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Des Moines to South Carolina

Best Price Found

$61

Fastest flight time

2h 16m

Direct flights

Every day

Airports in South Carolina

7 airports
The best one-way flight to South Carolina from Des Moines in the past 72 hours is $61. The best round-trip flight deal from Des Moines to South Carolina found on momondo in the last 72 hours is $178.
The fastest flight from Des Moines to South Carolina takes 2h 16m
Direct flights go from Des Moines to South Carolina every day.
There are 7 airports near South Carolina: Greenville (GSP), Columbia Metropolitan (CAE), Myrtle Beach Intl (MYR), Hilton Head Island (HHH), Savannah/Hilton Head (SAV), Charlotte Douglas (CLT), Charleston (CHS)

  • When did momondo last update prices for flights from Des Moines Airport to South Carolina?

    Prices for flights from Des Moines Airport to South Carolina refresh daily.

  • How many operators does momondo search for flights from Des Moines Airport to South Carolina?

  • How old do you have to be to fly from Des Moines Airport to South Carolina?

    The minimum age a child must be to fly alone is five but airlines that offer an unaccompanied minor (UNMR) service will have their own age restrictions, including rules around flight length, timings, and stopovers. We always recommend checking with the individual airline you are booking with to travel from Des Moines Airport to South Carolina.

  • What documentation or ID do you need to fly to South Carolina?

    The travel and health documents required for your trip to South Carolina can vary based on your itinerary and personal situation. As a rule, consider having multiple documents such as a national ID card or driver’s license, and a passport valid for six-months after you plan to arrive at South Carolina. We always recommend checking with your airline or a trusted third party such as IATA to get advice.


Best airlines flying from Des Moines to South Carolina

Compare and see reviews for airlines that fly from Des Moines to South Carolina with momondo
Airline
Rating
Free Cancellation
Price
DeltaPriceFrom $215Free CancellationRating
8.0
8,508 reviews
Search Delta flights
American AirlinesPriceFrom $244Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $248Free CancellationRating
7.4
8,970 reviews
Search United Airlines flights

Why use momondo?

Why should I use momondo to find a flight deal from Des Moines to South Carolina?

Finding the right flight to South Carolina from Des Moines is quick and easy when you have a range of options in front of you, from reputable agents and recognisable airlines. Options that can then be filtered down to find the best fit. That is what momondo does. We make finding flights to South Carolina quick and easy, saving you time and money.

Can I find flights from Des Moines to South Carolina with flexible booking policies on momondo?

Yes. momondo allows you to filter the results for Des Moines to South Carolina flights to just show those with flexible booking policies.

How can momondo help me find flights from Des Moines to South Carolina?

momondo helps you find the best flight between Des Moines and South Carolina by providing filters to narrow your choice of flights to those matching your criteria. You can select flights based on numerous factors such as price, departure and landing times, airport and airline.

I’m not ready to book a flight from Des Moines to South Carolina right now. Can momondo alert me if prices change?

Of course. momondo tracks the price of Des Moines to South Carolina flights. All you need is a valid email address and we will do the rest; it is that quick and easy.


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