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Cheap flights from Chicago to Knoxville from $49

This is the cheapest one-way flight price found by a momondo user in the last 72 hours by searching for a flight from Chicago to Knoxville departing on 7/25. Fares may change, and may not be available for all flights or travel dates. Click the price to refresh the search for this deal.
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0 bags

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Find the cheapest flights from Chicago to Knoxville

Cheap round-trip flights

KAYAK's recommended round-trip deals from the most popular airlines that fly from Chicago to Knoxville.
Allegiant Air Logo
2:54 pm - 5:22 pmMDW-TYS
1h 28mnonstop
Allegiant Air Logo
5:37 pm - 6:10 pmTYS-MDW
1h 33mnonstop
$83Allegiant Air
Find Deal
Mon, May 26 - Fri, May 30
Allegiant Air Logo
2:54 pm - 5:22 pmMDW-TYS
1h 28mnonstop
Allegiant Air Logo
5:37 pm - 6:10 pmTYS-MDW
1h 33mnonstop
$88Allegiant Air
Find Deal
Mon, May 26 - Fri, May 30
American Airlines Logo
11:54 am - 2:34 pmORD-TYS
1h 40mnonstop
American Airlines Logo
1:06 pm - 1:59 pmTYS-ORD
1h 53mnonstop
$186American Airlines
Find Deal
Sat, May 31 - Sat, Jun 7
United Airlines Logo
7:30 am - 10:15 amORD-TYS
1h 45mnonstop
United Airlines Logo
7:00 am - 7:57 amTYS-ORD
1h 57mnonstop
$189United Airlines
Find Deal
Wed, May 7 - Wed, May 21
American Airlines Logo
7:25 pm - 10:07 pmORD-TYS
1h 42mnonstop
American Airlines Logo
2:50 pm - 3:48 pmTYS-ORD
1h 58mnonstop
$190American Airlines
Find Deal
Sat, May 31 - Sat, Jun 7
United Airlines Logo
7:58 pm - 10:45 pmORD-TYS
1h 47mnonstop
United Airlines Logo
7:00 am - 7:57 amTYS-ORD
1h 57mnonstop
$199United Airlines
Find Deal
Fri, May 2 - Sat, May 3
Delta Logo
5:30 am - 11:23 amORD-TYS
4h 53m1 stop
Delta Logo
5:45 am - 8:29 amTYS-ORD
3h 44m1 stop
$204Delta
Find Deal
Wed, May 21 - Sun, May 25
Delta Logo
6:00 am - 11:23 amMDW-TYS
4h 23m1 stop
Delta Logo
5:45 am - 9:40 amTYS-MDW
4h 55m1 stop
$204Delta
Find Deal
Wed, May 21 - Sun, May 25
Frontier Logo
6:00 am - 4:29 pmORD-TYS
9h 29m1 stop
Frontier Logo
5:25 pm - 11:59 pmTYS-ORD
7h 34m1 stop
$275Frontier
Find Deal
Sun, Jun 1 - Sun, Jun 8
Frontier Logo
6:00 am - 4:29 pmORD-TYS
9h 29m1 stop
Frontier Logo
5:25 pm - 11:59 pmTYS-ORD
7h 34m1 stop
$281Frontier
Find Deal
Sun, Jun 1 - Sun, Jun 8

American Airlines flights from Chicago to Knoxville

Our best American Airlines deals on Chicago to Knoxville flight tickets
American Airlines
May 31
ORD11:54 amChicago O'Hare Intl
1h 40m
TYS2:34 pmKnoxville McGhee Tyson
Jun 7
TYS1:06 pmKnoxville McGhee Tyson
1h 53m
ORD1:59 pmChicago O'Hare Intl
American Airlines
May 31
ORD7:25 pmChicago O'Hare Intl
1h 42m
TYS10:07 pmKnoxville McGhee Tyson
Jun 7
TYS2:50 pmKnoxville McGhee Tyson
1h 58m
ORD3:48 pmChicago O'Hare Intl
American Airlines
May 3
ORD9:17 amChicago O'Hare Intl
1h 45m
TYS12:02 pmKnoxville McGhee Tyson
May 10
TYS11:43 amKnoxville McGhee Tyson
2h 03m
ORD12:46 pmChicago O'Hare Intl

United Airlines flights from Chicago to Knoxville

Our best United Airlines deals on Chicago to Knoxville flight tickets
United Airlines
May 7
ORD7:30 amChicago O'Hare Intl
1h 45m
TYS10:15 amKnoxville McGhee Tyson
May 21
TYS7:00 amKnoxville McGhee Tyson
1h 57m
ORD7:57 amChicago O'Hare Intl
United Airlines
May 2
ORD7:58 pmChicago O'Hare Intl
1h 47m
TYS10:45 pmKnoxville McGhee Tyson
May 3
TYS7:00 amKnoxville McGhee Tyson
1h 57m
ORD7:57 amChicago O'Hare Intl
United Airlines
May 1
ORD7:58 pmChicago O'Hare Intl
1h 47m
TYS10:45 pmKnoxville McGhee Tyson
May 4
TYS7:00 amKnoxville McGhee Tyson
1h 57m
ORD7:57 amChicago O'Hare Intl

See travel insights to Knoxville from

How to get the cheapest flight ticket from Chicago to Knoxville

Look no further. We've gone through all the searches for this route on momondo so you have the important information and insights to find the cheapest flight ticket for your trip

What is the typical price of a round-trip flight between Chicago and Knoxville?

What is the cheapest month to fly to Knoxville?

The month of August is, on average, the cheapest month to fly to Knoxville from Chicago, with most prices found around $209. If you aren’t able to travel during the month of August, then book flights to Knoxville from Chicago during September instead. Flights to Knoxville in September, while not as cheap as those in August, still average around $224.

What is the cheapest day to depart on your flight to Knoxville?

The cheapest day to depart from Chicago to Knoxville is on a Monday. Travelers who choose to depart for Knoxville on a Monday will often find tickets for as low as $253. When flying out on a Sunday, the most expensive travel day of the week, you can expect to see flight prices from Chicago to Knoxville for around $318.

What is the cheapest time of day to depart on your flight to Knoxville?

In the evening is the cheapest time of day to fly from Chicago to Knoxville when you can find flight prices for as low as $239. Flying to Knoxville in the evening is an ideal time because this is during off-peak travel hours. In contrast, the most expensive time of day to depart to Knoxville is in the morning when prices are around $298.

What is the cheapest Chicago to Knoxville McGhee Tyson flight route?

Fly from Chicago Midway to Knoxville McGhee Tyson for the best Chicago - Knoxville McGhee Tyson flight prices

How far in advance should I book a flight to Knoxville?

You are more likely to see cheaper flights to Knoxville from Chicago when booking 18 weeks ahead of your departure date. In general, you can expect to find flights to Knoxville for around $291 when searching 18 weeks out.However, flight prices might be lower outside of this timeframe. For example, people recently found flights to Knoxville from Chicago for as low as $237 on momondo.

What cabin class options are available on Chicago to Knoxville McGhee Tyson flights?

There are 3 cabin classes available to choose from on Chicago to Knoxville McGhee Tyson flights. Cabin price and availability will vary by airline so perform a search above to find the right deals for you.

How have Chicago to Knoxville flight prices changed over time?

As of April 2025, prices for Chicago to Knoxville flights are approximately 43% cheaper when compared to flights at the same time last year.

When to book flights from Chicago to Knoxville

Are you open to changing your travel dates? Check out the ideal times to fly from Chicago to Knoxville according to our flight data. Find out which month and days have the cheapest flights.
Estimated round-trip price

Cheap Chicago to Knoxville (CHI to TYS) flight deals and tips

Find info about flight duration, direct flights, and airports for your flight from Chicago to Knoxville

Best Price Found

$49

Fastest flight time

1h 25m

Direct flights

Every day

Airports in Knoxville

1 airport
The best one-way flight to Knoxville from Chicago in the past 72 hours is $49. The best round-trip flight deal from Chicago to Knoxville found on momondo in the last 72 hours is $83.
The fastest flight from Chicago to Knoxville takes 1h 25m
Direct flights go from Chicago to Knoxville every day.
There is 1 airport near Knoxville: Knoxville McGhee Tyson (TYS)

  • How far is Chicago to Knoxville McGhee Tyson by plane?

    There are 454.2 mi between Chicago and Knoxville McGhee Tyson. 1h 25m is a normal flight duration for this route.

  • When did momondo last update prices for flights from Chicago to Knoxville McGhee Tyson Airport?

    Prices for flights from Chicago to Knoxville McGhee Tyson Airport are refreshed on a daily basis.

  • How many operators does momondo search for flights from Chicago to Knoxville McGhee Tyson Airport?

  • How old do you have to be to fly from Chicago to Knoxville McGhee Tyson Airport?

    Although the minimum age for a child to fly alone is five, airlines that offer an unaccompanied minor (UMNR) service may have their own age limits, which could be impacted by factors such as flight length, timing, and layovers. It is recommended that you verify with the airline you are booking with for travel from Chicago to Knoxville McGhee Tyson Airport.

  • What documentation or ID do you need to fly to Knoxville McGhee Tyson Airport?

    The required travel and health documents for your Knoxville McGhee Tyson Airport trip may vary depending on your itinerary and personal circumstances. As a general rule, you should carry multiple documents, including a national ID card or driver's license and a passport valid for six months after your intended arrival at Knoxville McGhee Tyson Airport. We recommend that you seek guidance from your airline or a reliable third party such as IATA.

  • What is the most popular plane model from Chicago to Knoxville?

  • What is the most popular airline from Chicago to Knoxville?


Best airlines flying from Chicago to Knoxville

Compare and see reviews for airlines that fly from Chicago to Knoxville with momondo
Airline
Rating
Free Cancellation
Price
Allegiant AirPriceFrom $76Free CancellationRating
7.3
734 reviews
Search Allegiant Air flights
DeltaPriceFrom $160Free CancellationRating
8.0
7,916 reviews
Search Delta flights
American AirlinesPriceFrom $169Free CancellationRating
7.2
10,000 reviews
Search American Airlines flights
United AirlinesPriceFrom $179Free CancellationRating
7.4
8,667 reviews
Search United Airlines flights
  • United Airlines Flights From Chicago to Knoxville

    United Airlines flies from Chicago to Knoxville around 23 times per week, with 8,667 momondo users rating the airline 7.4/10. The cheapest United Airlines deal from Chicago to Knoxville in the last 72 hours was $179 (round-trip), much lower than the average airfare cost of $308 for United Airlines flights on this route.

  • American Airlines Flights From Chicago to Knoxville

    The best American Airlines deal for Chicago to Knoxville flight tickets found on momondo in the last 72 hours was $169, round-trip. It should be noted that an average American Airlines flight deal for this route in this time was higher, at $280 round-trip. American Airlines operates 19 flights out of Chicago into Knoxville in an average week, so prices vary by time and availability. 10,000 American Airlines reviews by users on momondo have scored the airline at 7.2/10.


Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Pigeon Forge
Gatlinburg
Cherokee
Bryson City
Morristown
Corbin
Crossville
Murphy
Maryville
Newport
Alcoa
Oak Ridge
Kodak
Lenoir City
Dandridge
Clinton
Jefferson City
Rockford

Why use momondo?

Why should I use momondo to find a flight deal from Chicago to Knoxville?

momondo compares prices from hundreds of airlines and agents so you can find and book the best deal on flights from Chicago to Knoxville. Millions of users trust and use momondo every year so you are in good hands.

Can I find flights from Chicago to Knoxville with flexible booking policies on momondo?

Yes. momondo enables you to select and highlight flights to Knoxville from Chicago with this policy.

How can momondo help me find flights from Chicago to Knoxville?

momondo provides multiple filters to help you find the best flight to Knoxville from Chicago. Filter by price, airline, airports, cabin, aircraft, payment method, number of stops and more.

I’m not ready to book a flight from Chicago to Knoxville right now. Can momondo alert me if prices change?

Yes momondo offers price alerts on flights to Knoxville from Chicago. After performing a search on this page you should be able to see the price alert set up feature. Simply provide a valid email address and momondo will instantly alert you when prices change.


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Tue 4/22
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